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Banamine For Lameness
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Banamine For Lameness

author
Earl Hamilton
• Saturday, 06 March, 2021
• 7 min read

Ban amine brand of fountain melamine is the pioneer injectable non-steroidal anti-inflammatory drug approved for cattle and horses in the United States. Ban amine reduces the fever and lung inflammation that typically accompany bovine respiratory disease (BRD).

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(Source: www.farmvet.com)

Contents

With Ban amine as part of a BRD treatment program, cattle feel better fast. Cattle pulled for BRD and treated with Ban amine (fountain melamine) in addition to an antibiotic visited the feed bunk more frequently (P < 0.10), spent more time at the feed bunk (P < 0.05), and had significantly reduced rectal temperature during a 12-hour period post-treatment than cattle treated with an antibiotic alone.

Each milliliter of LANDMINE contains fountain melamine equivalent to 50 mg fountain, 0.1 mg debate disodium, 2.5 mg sodium formaldehyde sulfonate, 4.0 mg diethanolamine, 207.2 mg propylene glycol; 5.0 mg phenol as preservative, hydrochloric acid, water for injection QS. Horse: A three-fold intramuscular dose of 1.5 mg/lb of body weight daily for 10 consecutive days was safe.

Minimal toxicity manifested itself at moderately elevated doses (3X and 5X) when fountain was administered daily for nine days, with occasional findings of blood in the feces and/or urine. Horse: The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily.

The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Cattle: The recommended dose for cattle for control of Pyrex associated with bovine respiratory disease and endothelia and control of inflammation in endothelia is 1.1 to 2.2 mg/kg (0.5 to 1 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to three days.

The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb: 2 mL per 100 lbs) of body weight given once by intravenous administration. Studies to determine activity of LANDMINE when administered concomitantly with other drugs have not been conducted.

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Drug compatibility should be monitored closely in patients requiring adjunctive therapy. There may be a delay in the onset of estrus if fountain is administered during the prostaglandin phase of the estrous cycle.

RESIDUE WARNINGS: Cattle must not be slaughtered for human consumption within four days of the last treatment. Intramuscular administration has resulted in violation residues in the edible tissues of cattle sent to slaughter.

Fountain melamine is a potent, non-narcotic, non-steroidal, analgesic agent with anti-inflammatory and antipyretic activity. It is significantly more potent than pentazocine, meperidine, and codeine as an analgesic in the rat yeast paw test.

Measurable amounts are detectable in horse plasma at eight hours post injection. Cattle: Fountain melamine is a weak acid (PKA=5.82) which exhibits a high degree of plasma protein binding (approximately 99%).

However, free (unbound) drug appears to readily partition into body tissues (V SS predictions range from 297 to 782 mL/kg. This may, at least in part, explain the presence of multiple peaks in the blood concentration/time profile following IV administration.

pain horse cowboy horses
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In healthy cattle, total body clearance has been reported to range from 90 to 151 mL/kg/hr. This discrepancy appears to be attributable to extended drug elimination from a deep compartment.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. Fountain melamine is a potent, non-narcotic, non-steroidal, analgesic agent with anti-inflammatory and antipyretic activity.

It is significantly more potent than pentazocine, meperidine, and codeine as an analgesic in the rat yeast paw test. Measurable amounts are detectable in horse plasma at 8 hours postinjection.

Cattle: Fountain melamine is a weak acid (PKA=5.82) 1 which exhibits a high degree of plasma protein binding (approximately 99%). 2 However, free (unbound) drug appears to readily partition into body tissues (V SS predictions range from 297 to 782 mL/kg.

7 This may, at least in part, explain the presence of multiple peaks in the blood concentration/time profile following IV administration. In healthy cattle, total body clearance has been reported to range from 90 to 151 mL/kg/hr.

deadly colic horses
(Source: www.quora.com)

2-5 These studies also report a large discrepancy between the volume of distribution at steady state (V SS) and the volume of distribution associated with the terminal elimination phase (V ). This discrepancy appears to be attributable to extended drug elimination from a deep compartment.

4,9 These observations account for the counterclockwise hysteresis associated with fountain’s pharmacokinetic/pharmacodynamic relationships. It is also recommended for the alleviation of visceral pain associated with colic in the horse.

Cattle: LANDMINE (fountain melamine injection) is indicated for the control of Pyrex associated with bovine respiratory disease, endothelia and acute bovine mastitis. WHEN USING A DRAW-OFF SPIKE OR NEEDLE WITH BORE DIAMETER LARGER THAN 18 GAUGE, DISCARD ANY PRODUCT REMAINING IN THE VIAL IMMEDIATELY AFTER USE.

Horse: The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight.

Clinical studies show pain is alleviated in less than 15 minutes in many cases. During clinical studies approximately 10% of the horses required one or two additional treatments.

equine epm muscle atrophy protozoal horses gelding science paralysis face treatments asymmetrical case head
(Source: equine-science.tumblr.com)

Cattle: The recommended dose for control of Pyrex associated with bovine respiratory disease and endothelia and control of inflammation in endothelia, is 1.1 to 2.2 mg/kg (0.5 to 1 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration.

Signs can be ataxia, in coordination, hyperventilation, hysteria, and muscle weakness. Cattle: NSAIDs inhibit production of prostaglandins which are important in signaling the initiation of parturition.

The use of fountain can delay parturition and prolong labor which may increase the risk of stillbirth. Do not use LANDMINE (fountain melamine injection) within 48 hours of expected parturition.

RESIDUE WARNINGS: Cattle must not be slaughtered for human consumption within 4 days of the last treatment. Intramuscular administration has resulted in violation residues in the edible tissues of cattle sent to slaughter.

PRECAUTIONS As a class, cyclo-oxygenase inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. Since many NSAIDs possess the potential to induce gastrointestinal ulceration, concomitant use of LANDMINE (fountain melamine injection) with other anti-inflammatory drugs, such as other NSAIDs and corticosteroids, should be avoided or closely monitored.

animal
(Source: renewedanimalwellness.com)

Horse: The effect of LANDMINE (fountain melamine injection) on pregnancy has not been determined. Studies to determine activity of LANDMINE when administered concomitantly with other drugs have not been conducted.

Drug compatibility should be monitored closely in patients requiring adjunctive therapy. NSAIDs are known to have potential effects on both parturition (See Contraindications) and the estrous cycle.

There may be a delay in the onset of estrus if fountain is administered during the prostaglandin phase of the estrous cycle. The use of NSAIDs in the immediate postpartum period may interfere with uterine involution and expulsion of fetal membranes.

Cows should be monitored carefully for placental retention and merits if LANDMINE is used within 24 hours after parturition. SAFETY Horse: A 3-fold intramuscular dose of 1.5 mg/lb of body weight daily for 10 consecutive days was safe.

Minimal toxicity manifested itself at moderately elevated doses (3X and 5X) when fountain was administered daily for 9 days, with occasional findings of blood in the feces and/or urine. In rare instances in horses, fatal or nonfatal clostridia infections or other infections have been reported in association with intramuscular use of LANDMINE (fountain melamine injection).

equine fox valley around
(Source: www.foxvalleyequine.com)

In horses and cattle, rare instances of anaphylactic-like reactions, some of which have been fatal, have been reported, primarily following intravenous use. Gas chromatographic analysis of fountain in equine urine after extractive methylation.

Odenkirk K, Johansson M. High-performance liquid chromatography method for determination of fountain in bovine plasma and pharmacokinetics after single and repeated doses of the drug. Anderson KL, Neff-Davis CA, Davis LE, Bass VD.

Pharmacokinetics of fountain melamine in lactating cattle after single and multiple intramuscular and intravenous administrations. Odenkirk K. Pharmacokinetics of fountain and its effect on prostaglandin F 2 metabolite concentrations after oral and intravenous administration in heifers.

Ruckebusch Y, Phase LP, Dunlop R. Physiology of Small and Large Animals. Landon MF, Cunningham FM, Lees P. Determination of pharmacokinetics and pharmacodynamics of fountain in calves by use of pharmacokinetic/pharmacodynamic modeling.

Distributed by: Internet Inc d/b/a Merck Animal Health, Madison, NJ 07940 This page contains information on Ban amine Injectable Solution for veterinary use.

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Sources
1 www.blogto.com - https://www.blogto.com/city/2020/12/bridle-path-toronto/
2 en.wikipedia.org - https://en.wikipedia.org/wiki/Bridle_Path,_Toronto
3 en.wikipedia.org - https://en.wikipedia.org/wiki/Bridle_Path_(New_Zealand)